FOLATE CONJUGATED PHOSPHORYLCHOLINE-POLYCATIONCOPOLYMERS FOR GENE DELIVERY

机译：叶酸偶联的磷脂酰胆碱-聚合共聚物，用于基因转移

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Newly synthesized folate-conjugated 2-(dimethylamino)ethyl methacrylate–block-2-(methacryloyloxyethyl phosphorylcholine) (DMAMPC)copolymer was studied for its potential use asa gene delivery system. This novel synthetic vectorcan form colloidally-stable DNA complexes withparticle size below 120 nm, protects the DNA fromenzymatic degradation and leads to increasedtransfection efficiency for certain cell lines.

机译：新合成的叶酸共轭2- 甲基丙烯酸（二甲基氨基）乙酯–嵌段-2- （甲基丙烯酰氧基乙基磷酰胆碱）（DMAMPC）对共聚物的潜在用途进行了研究基因传递系统。这种新颖的合成载体可以与小于120 nm的粒径，可保护DNA免受酶促降解并导致增加某些细胞系的转染效率。

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《Annual meeting exposition of the Controlled Release Society》|2005年|1-2|共2页
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Jenny Lam; Andrew Lewis; Steve Armes; Tom Baldwin; Snjezana Stolnik;
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中图分类药学;
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1. Modular Synthesis of Folate Conjugated Ternary Copolymers: Polyethylenimine-graft-Polycaprolactone-block-Poly(ethylene glycol)-Folate for Targeted Gene Delivery [J] . Li Liu, Mengyao Zheng, Thomas Renette Bioconjugate Chemistry . 2012,第6期

机译：叶酸共轭三元共聚物的模块合成：聚乙烯亚胺-接枝-聚己内酯-嵌段-聚（乙二醇）-叶酸酯用于靶向基因的传递
2. Folate-conjugated gene-carrying microbubbles with focused ultrasound for concurrent blood-brain barrier, opening and local gene delivery [J] . Fan Ching-Hsiang, Chang En-Ling, Ting Chien-Yu, Biomaterials . 2016,第Null期

机译：叶酸偶联的携带基因的微泡，聚焦超声，用于同时发生血脑屏障，开放和局部基因递送
3. Folate-conjugated gene-carrying microbubbles with focused ultrasound for concurrent blood-brain barrier, opening and local gene delivery [J] . Fan Ching-Hsiang, Chang En-Ling, Ting Chien-Yu, Biomaterials . 2016,第Null期

机译：叶酸偶联的携带基因的微泡，聚焦超声，用于同时发生血脑屏障，开放和局部基因递送
4. Folate conjugated fluorescent silica nanoparticles for folate receptor-positive tumors targeting delivery and their internalization mechanism investigation [C] . Mingming Xu, Changchun Lou, Hong Yang, World biomaterials congress . 2012

机译：叶酸共轭荧光二氧化硅纳米粒子用于叶酸受体阳性肿瘤的靶向递送及其内在机理研究
5. The modulatory effects of folate deficiency on mRNA and/or protein expression of the genes involved in folate metabolism and one-carbon transfer reactions using an in vitro folate deficient model of colorectal cancer. [D] . Hayashi, Inki. 2005

机译：使用体外结直肠癌的叶酸缺乏模型，叶酸缺乏对参与叶酸代谢和单碳转移反应的基因的mRNA和/或蛋白质表达的调节作用。
6. Gefitinib loaded folate decorated bovine serum albumin conjugated carboxymethyl-beta-cyclodextrin nanoparticles enhance drug delivery and attenuate autophagy in folate receptor-positive cancer cells [O] . Yijie Shi, Chang Su, Wenyu Cui, 2014

机译：吉非替尼负载的叶酸修饰的牛血清白蛋白缀合的羧甲基-β-环糊精纳米颗粒可增强药物传递并减弱叶酸受体阳性癌细胞中的自噬。
7. Gefitinib loaded folate decorated bovine serum albumin conjugated carboxymethyl-beta-cyclodextrin nanoparticles enhance drug delivery and attenuate autophagy in folate receptor-positive cancer cells [O] . 2014

机译：吉非替尼负载的叶酸修饰的牛血清白蛋白缀合的羧甲基-β-环糊精纳米颗粒可增强药物传递并减弱叶酸受体阳性癌细胞中的自噬。

FOLATE CONJUGATED PHOSPHORYLCHOLINE-POLYCATIONCOPOLYMERS FOR GENE DELIVERY

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