Development of a Non-Viral DNA Vector Multifunctional Envelop-type Nano Device

摘要

We constructed a novel non-viral DNA vectornamed a multifunctional envelope-type nano device(MEND). The transfection activity of the MENDmodified with octaarginine peptide (R8-MEND) wasas high as that of adenovirus. The high transgeneability of R8-MEND was found to result from efficientintracellular trafficking via a macropinocytosis.