Liposome Bilayer Mechanics and its Effect on Transfection Efficiency of Plasmid DNA in vitro

机译：脂质体双层力学及其对质粒DNA体外转染效率的影响

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Liposome-DNA complexes (I.e. lipoplexes)composed of DOPE yield higher levels oftransfection than when replaced with cholesterol.Additionally, when egg phosphotidylcholine (PC) isincluded in the vesicle bilayer transfection efficiencyis reduced even further, where the liposomes bilayeris stabilised and rendered more rigid, preventingendosomal disruption and delivery of plasmid DNAinto the cytoplasm.

机译：脂质体-DNA复合物（即脂质复合物）由DOPE组成的产品具有更高的含量转染时比用胆固醇代替。此外，当卵磷脂囊泡双层转染效率在脂质体双层的情况下被进一步降低稳定并变得更坚硬，可防止内体破坏和质粒DNA的传递进入细胞质。

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《Annual meeting exposition of the Controlled Release Society》|2005年|1-2|共2页
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Sarah McNeil; Peter Hanson; Yvonne Perrie;
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中图分类药学;
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3. Time-dependent complex formation of dendritic poly(L-lysine) with plasmid DNA and correlation with in vitro transfection efficiencies [J] . Tatsuya Okuda, Satoru Kidoaki, Mio Ohsaki, Organic & biomolecular chemistry . 2003,第8期

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Liposome Bilayer Mechanics and its Effect on Transfection Efficiency of Plasmid DNA in vitro

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