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From RNA Secondary Structure to Coding Theory: A Combinatorial Approach

机译:从RNA二级结构到编码理论:组合方法

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We use combinatorial analysis to transform a special case of the computational problem of designing RNA base sequences with a given minimal free energy secondary structure into a coding theory question. The function of RNA molecules is largely determined by their molecular form, which in turn is significantly related to the base pairings of the secondary structure. Hence, this is crucial initial work in the design of RNA molecules with desired three-dimensional structures and specific functional properties. The biological importance of RNA only continues to grow with the discoveries of many different RNA molecules having vital functions other than mediating the production of proteins from DNA. Furthermore, RNA has the same potential as DNA in terms of nanotechnology and biomolecular computing.
机译:我们使用组合分析将设计具有给定的最小自由能二级结构的RNA基本序列的计算问题的特例转换为编码理论问题。 RNA分子的功能很大程度上取决于其分子形式,而分子形式又与二级结构的碱基配对显着相关。因此,这对于设计具有所需三维结构和特定功能特性的RNA分子至关重要。随着许多不同的具有重要功能的RNA分子的发现,除了介导DNA蛋白质的生产外,RNA的生物学重要性也一直在不断增长。此外,就纳米技术和生物分子计算而言,RNA具有与DNA相同的潜力。

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