EVALUATION OF·δ-VALEROLACTONE/PEG AND E-CAPROLACTONE/PEG TRIBLOCK MICELLES

摘要

The aim of this study was to evaluate the possibility of triblock copolymeric micelles as a drug carrier. The synthetic amphiphilic copolymers were spontaneously formed micelles with a low CMC value less than 5.77 x 10~(-7) M. The loading efficiency of indomethacin in δ-VL/PEG_(4000) micelles was higher than that in ε-CL/PEG_(4000) micelles, which increased as copolymers with low CMC and long poly(lactone) chain length. The release of indomethacin from copolymeric micelles exhibited a sustained-release character.