PROTEIN AND ADJUVANT CO-ENCAPSULATED IN PLG MICROSPHERES ELICIT A STRONG COMPREHENSIVE IMMUNE RESPONSE AGAINST A M. TUBERCULOSIS ANTIGEN

机译：蛋白和佐剂共包被在PLG微球中，可引起针对结核分枝杆菌抗原的强力综合免疫反应

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A protein microsphere vaccine was developed for the tuberculosis antigen Mtb8.4 that elicited antigen specific cellular and humoral immune responses. Co-encapsulation of the adjuvant MPL~(~R) in the microspheres further enhanced these responses. Moreover, strong cellular and humoral responses were obtained following a single immunization with a low dose (0.37

机译：已开发出一种针对结核抗原Mtb8.4的蛋白质微球疫苗，该疫苗引发了抗原特异性的细胞和体液免疫反应。在微球中共封装佐剂MPL〜（〜R）进一步增强了这些反应。此外，低剂量（0.37）的单次免疫后获得了强烈的细胞和体液反应

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《Proceedings of the 29th Annual Meeting of the Controlled Release Society》|2002年|p.60-61|共2页
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J.T. Evans; J.R. Ward; J. Kern; M.E. Johnson;
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中图分类化学工业;
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microspheres; T cell vaccine; protein delivery; adjuvant;

机译：微球; T细胞疫苗;蛋白质递送;佐剂;

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专利

1. A single vaccination with protein-microspheres elicits a strong CD8 T-cell-mediated immune response against Mycobacterium tuberculosis antigen Mtb8.4 [J] . Evans JT, Ward JR, Kern J, Vaccine . 2004,第15a16期

机译：蛋白质微球的单次疫苗接种引起针对结核分枝杆菌抗原Mtb8.4的强CD8 T细胞介导的免疫反应
2. Novel adjuvant for immunization against tuberculosis: DNA vaccine expressing Mycobacterium tuberculosis antigen 85A and interleukin-15 fusion product elicits strong immune responses in mice [J] . Biotechnology Letters . 2017,第8期

机译：对结核病免疫的新佐剂：表达结核分枝杆菌抗原85a和白细胞介素-15融合产物的DNA疫苗引发了小鼠的强免疫应答
3. The extracellular matrix protein mindin as a novel adjuvant elicits stronger immune responses for rBAG1, rSRS4 and rSRS9 antigens of Toxoplasma gondii in BALB/c mice [J] . Xiaojing Sun, Mei Mei, Xu Zhang, BMC Infectious Diseases . 2014,第1期

机译：细胞外基质蛋白介素作为一种新型佐剂，可对BALB / c小鼠弓形体的rBAG1，rSRS4和rSRS9抗原产生更强的免疫反应
4. PROTEIN AND ADJUVANT CO-ENCAPSULATED IN PLG MICROSPHERES ELICIT A STRONG COMPREHENSIVE IMMUNE RESPONSE AGAINST A M. TUBERCULOSIS ANTIGEN [C] . J.T. Evans, J.R. Ward, J. Kern, Annual meeting of the Controlled Release Society . 2002

机译：蛋白质和佐剂在PLG微球中封装在PLG微球中，从而强烈的综合免疫应答抗原抗原
5. Potentiation of the immune response with aluminum-containing adjuvants: I. Distribution of adsorbed antigen in mono-valent and combination vaccines; II. Role of antigen adsorption in antigen internalization by dendritic cells. [D] . Morefield, Garry Lee, Jr. 2003

机译：含铝佐剂增强免疫应答：I.单价和组合疫苗中吸附抗原的分布；二。抗原吸附在树突状细胞的抗原内在化中的作用。
6. The extracellular matrix protein mindin as a novel adjuvant elicits stronger immune responses for rBAG1 rSRS4 and rSRS9 antigens of Toxoplasma gondiiin BALB/c mice [O] . Xiaojing Sun, Mei Mei, Xu Zhang, 2014

机译：细胞外基质蛋白介素作为一种新型佐剂可对弓形虫BALB / c小鼠的rBAG1rSRS4和rSRS9抗原产生更强的免疫反应
7. The extracellular matrix protein mindin as a novel adjuvant elicits stronger immune responses for rBAG1, rSRS4 and rSRS9 antigens of Toxoplasma gondiiin BALB/c mice [O] . Xiaojing Sun, Mei Mei, Xu Zhang, 2014

机译：细胞外基质蛋白介素作为一种新型佐剂，可对弓形虫BALB / c小鼠的rBAG1，rSRS4和rSRS9抗原产生更强的免疫反应

PROTEIN AND ADJUVANT CO-ENCAPSULATED IN PLG MICROSPHERES ELICIT A STRONG COMPREHENSIVE IMMUNE RESPONSE AGAINST A M. TUBERCULOSIS ANTIGEN

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