The paper analyzes the regimes and conditions of a long series of flight single crystals growth experiments using various technique of directional crystallization during the missions starting from "Apollo - Soyuz" through "Salyut-6" - "Soyuz" to the recent "Photons". The single crystals of germanium doped with silicon, gallium, indium, antimonium and also of indium antimonide doped with tellurium have been grown and studied. Research results of the component segregation are discussed anew for these single crystals as well as for the melt of indium antimonide - indium bismuth system. For the first time the results of segregation studies obtained in experiments on various spacecraft are comparing with gravity conditions on these vehicles. It is show that uncontrollable quasi-stationary microaccelerations with magnitude more than 10~(-6) g_o are those forces leading to uncontrollable component segregation.
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