Electroporation of Bone Tissue: Implications for Use in the Treatment of Bone Metastasis with Electrochemotherapy

摘要

Electrical pulses were applied to the distal femur of rabbits by inserting four electrodes in order to evaluate if and to what extent cell electroporation could be achieved in such a non-homogenous tissue. Dose response effect of number of pulses delivered was observed. 120 pulses at 1750V7cm successfully removed all osteogenetic activity among the electrodes, as evidenced by tetracyclin staining. These preclinical results lay the foundation for use of electroporation in the treatment of bone metastases.