MEASUREMENT METHOD FOR HYDROXYLATED POLYCHLORINATED BIPHENYLS (OH-PCBs) IN BLOOD BY LC/MS/MS

摘要

We developed measurement method for hydroxylated chlorinated biphenyls concentrations in human blood samples using a LC/MS/MS with an electrospray ionization interface in negative ion and selective reaction monitoring mode. This developed method is effective to determine the concentrations of PCDDs, PCDFs, Co-PCBs and OH-PCBs at the same time without a derivatization of a sample. The major OH-PCB metabolites were 4-OH-CB187, 4-OH-CB146 and 4-OH-CB107 + 3-OH-CB118 in human blood samples.