Role of Agrin as a major mediator of effects of laser light on nervous tissue

摘要

During the past 20 years, several researchers have found varying results in the effect of lasers on neural growth or function. The mechanisms of influence of laser light interaction with nerve tissues have not been clarified so far. Agrin should be considered as a possible mediator of light effects on nerve tissues. This meta-analysis hypothesizes that functional changes of agrin by light may explain these variable results in previous laser experiments. Agrin is one of the main regulating mechanisms in neural function and growth. Effective interactions between cells and their environment often rely on the creation, maintenance, and regulation of specialized membrane domains. Such domains are typically comprised of selected cytoskeletal, signaling, and adhesion molecules. How are such domain-specific specializations formed and maintained? A large body of work has established that the neuromuscular junction is induced by the secretion of agrin from the nerve terminal.