Crosslinked Electrospun UPM/PHBV/PVP Fibers for Sustained Drug Release

摘要

Crosslinked UPM/PHBV/PVP fibers were successfully prepared using electrospinning process. The active pharmaceutical ingredient tetracycline hydrochloride (TH) was loaded onto the electrospun fibers through after-treatment method. Scanning electron microscopy (SEM), Fourier-transform infrared (FTIR) and in vitro dissolution tests were carried out to characterize the medicated electrospun fibers. The SEM and FTIR results clearly showed the difference between the UPM / PHBV and UPM/ PHBV/ PVPelectrospun fibers. The pharmaceutical tests results indicated that the fibers had good drug-loaded capability and sustained-release properties. The as-prepared fibers might find possible applications as wound dressings or transdermal drug delivery systems.