Comparative evaluation of photodynamic activity of several HpD and different samples of sulphonated aluminum phthalocyanine

摘要

Abstract: Three samples of sulphonated aluminum phthalocyanine with predominance of different sulphonated degree (AlPcSn) were investigated in vivo in comparison with different commercial samples of HpD. The criterium of primary biological assessment of photodynamic activity was the field of necrosis spot upon the liver tissue of mice under the same parameters of influence combination. The preliminary experimental and morphological study of antitumor activity demonstrates different mechanisms of photodynamic activity when we use for PDT more effective di- and trisulphonated phthalocyanine Al and most effective from HpD - Photofrin II. !4