NON-TOXIC ESCHERICHIA C0ULT MUTANTS AND SUPRA-MOLECULAR BIOVECTOR SYSTEM (SMBV~(TM)) FOR INTRANASAL IMMUNIZATION WITH MENINGOCOCCAL CONJUGATED VACCINES

摘要

Non toxic E. coli LT mutants and Supra-molecular Biovector systems were evaluated for intranasal immunization of mice with the group C meningococcal conjugated vaccine. The results obtained show that LT mutants and SMBV? are very promising candidates for the preparation of vaccines for intranasal delivery of vaccines.