Combined Optical Coherence Tomography based on the Extended Huygens-Fresnel Principle and Histology of mouse-skin

摘要

Noninvasive measurement technique to obtain tissue optical properties such as the scattering coefficient μ_s and the anisotropy factor g using optical coherence tomography (OCT) scattering model which based on the Extended Huygens-Fresnel principle is developed in our paper. Older and younger mouse-skin are as animal model to compare its scattering coefficient μ_s and the anisotropy factory, the outcome shows that scattering coefficient μ_s is increased with the age of mouse-skin. Furthermore, we have made age's mouse-skin into H.E stain slices; the result of its morphology is consistent with the OCT imaging and OCT-EHF principle. All of that have provided the theoretical basis which to the research on photo-aging skin and photo-rejuvenation.