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首页> 外文会议>Optics in health care and biomedical optics VIII >Detection of Oligomerization of Epstein-Barr virus Oncoprotein LMP1 by FRET-Based Probes
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Detection of Oligomerization of Epstein-Barr virus Oncoprotein LMP1 by FRET-Based Probes

机译：基于FRET的探针检测爱泼斯坦-巴尔病毒癌蛋白LMP1的低聚

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摘要

In this study, two FRET-based probes are constructed to research oligomerization of Epstein-Barr virus Oncoprotein LMP1 in live cells. The images of wide-field fluorescence microscopy display that the majority of two LMP1-associated probes co-localized in internal perinuclear membranes. Furthermore, the fluorescence spectra of single cell co-expressed two probes indicated that the ratio of two emission peaks is around one, and the fluorescence spectra changed insignificantly during an hour observation. These findings indicated that LMP1/LMP1 interacted stably in live cells.
机译：在这项研究中，构建了两个基于FRET的探针来研究爱泼斯坦-巴尔病毒癌蛋白LMP1在活细胞中的寡聚。宽视场荧光显微镜的图像显示，大多数两个与LMP1相关的探针共定位在内部核周膜中。此外，单细胞共表达两种探针的荧光光谱表明，两个发射峰的比率约为一个，并且在一个小时的观察过程中，荧光光谱的变化很小。这些发现表明LMP1 / LMP1在活细胞中稳定地相互作用。

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  • 来源
    《Optics in health care and biomedical optics VIII》|2018年|108201T.1-108201T.6|共6页
  • 会议地点 Beijing(CN)
  • 作者

    Zhiwei Wu; Qing Ye; Jing Li; Yimei Huang; Yating Lin; Mengmeng Zheng; Shusen Xie; Juqiang Lin;

  • 作者单位

    MOE Key Laboratory of Optoelectronic Science and Technology for Medicine and Fujian Provincial Key Laboratory for Photonics Technology, Fujian Normal University, Fuzhou 350007, China;

    Department of Otolaryngology, Provincial Clinical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou, 350001, China;

    Department of Otolaryngology, Provincial Clinical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou, 350001, China;

    MOE Key Laboratory of Optoelectronic Science and Technology for Medicine and Fujian Provincial Key Laboratory for Photonics Technology, Fujian Normal University, Fuzhou 350007, China;

    MOE Key Laboratory of Optoelectronic Science and Technology for Medicine and Fujian Provincial Key Laboratory for Photonics Technology, Fujian Normal University, Fuzhou 350007, China;

    MOE Key Laboratory of Optoelectronic Science and Technology for Medicine and Fujian Provincial Key Laboratory for Photonics Technology, Fujian Normal University, Fuzhou 350007, China;

    MOE Key Laboratory of Optoelectronic Science and Technology for Medicine and Fujian Provincial Key Laboratory for Photonics Technology, Fujian Normal University, Fuzhou 350007, China;

    MOE Key Laboratory of Optoelectronic Science and Technology for Medicine and Fujian Provincial Key Laboratory for Photonics Technology, Fujian Normal University, Fuzhou 350007, China;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    nasopharyngeal carcinoma; LMP1; oligomerization; FRET; fluorescence protein; fusion protein; fluorescence spectra; fluorescence image;

    机译：鼻咽癌LMP1；低聚烦恼;荧光蛋白融合蛋白荧光光谱荧光图像;

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