Evaluation of short-term degradation of bicomponent electrospun fibres via AFM analysis

摘要

In this study, AFM analysis has been properly set to estimate the Gelatin loss from fibre surface during SCM treatment. Results showed a progressive slowing of the hydrolytic degradation of protein which does not significantly alter fibrous structure. An increase of surface roughness as well as a decrease of fibre diameter have been detected. In this context, Gelatin release coupled with improved roughness of fibres surface should similarly occur in cell culture, positively influencing the basic mechanisms of cell adhesion and spreading, this better mimicking the real microenvironment of natural tissues.