A Spray Freeze Dried Powder for Liposomal Inhaled Aerosol DrugDelivery

摘要

In this paper, a novel powder formulation for inhaledaerosol drug delivery of liposomes has been preparedusing spray-freeze drying. Aerosol dispersion propertiesof this formulation were assessed using a new passiveinhaler (patent pending), in which the powder wasentrained at a flow rate of 60 l/min. Excellent fine particlefraction (FPF) of more than 80% was achieved for thisformulation with a model drug (ciprofloxacin). Dispersionof powder in various aqueous media gave drugencapsulation efficiencies as follows: 50% in water,93.5% in isotonic saline, 80% in bovine mucin, 75% inporcine mucus and 73% in fivefold diluted ex vivo humancystic fibrosis patient sputum.