PEG-Insulin Conjugates for Optimal Microsphere Formulations

摘要

PEGylation protects proteins and peptides fromrnthe harsh conditions required for encapsulation inrnand delivery from biodegradable microspheres. Wernshow here that PEG molecular weight and site ofrnPEG conjugation are major factors that determinernthe stability and activity of the conjugated protein, asrnwell as the initial burst and subsequent release fromrnmicrospheres.