EFFECT OF MOLECULAR WEIGHT AND DEGREE OF DEACETYLATIONON CHITOSAN-DNA NANOPARTICLES

摘要

Mw and DD of chitosan affected cellular uptake ofchitosan-DNA nanoparticles and the ability ofchitosan to protect the DNA against nucleases. Lackof protection and poor cellular uptake led to low invitro transfection efficiency for nanoparticles preparedwith chitosan of low Mw or low DD.