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Mid-IR evanescent-wave sensors for tiny biological samples

机译:中红外biological逝波传感器,用于微小的生物样品

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Abstract: We have developed methods for embedding miniature planar IR sensor elements flush at the surface of rigid substrates. The planar Ge waveguides have thicknesses down to approximately 10 micron, and widths of 0.5-1 mm. These waveguides are tapered in thickness along their 50-mm lengths to permit efficient coupling of light into the approximately 10 micron sensing region without requiring an IR microscope. The waveguides can therefore be positioned with their sensor surface horizontal. Such waveguides can be used as mid-IR evanescent-wave sensor elements for small biological samples. They display exquisite sensitivity to small numbers of analyte molecules at their surface. It is possible to collect high-throughput broadband spectra, e.g. of tiny liquid droplets or membranes of individual cells, in a matter of seconds. !6
机译:摘要:我们已经开发出了将微型平面红外传感器元件平齐嵌入刚性基板表面的方法。平面Ge波导的厚度低至大约10微米,并且宽度为0.5-1mm。这些波导的厚度沿其50毫米长度逐渐变细,以允许将光有效耦合到大约10微米的感应区域,而无需使用红外显微镜。因此,可以以其传感器表面水平放置波导。这种波导可用作小型生物样品的中红外渐逝波传感器元件。它们对表面的少量分析物分子显示出极好的敏感性。可以收集高通量宽带频谱,例如在几秒钟内就能形成单个细胞的微小液滴或膜。 !6

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