DYNAMIC RESPONSE OF NORMAL AND OSTEOPOROTIC TRABECULAR BONE BY VIBRATION ANALYSIS

摘要

Osteoporosis afflicts about 200 million people worldwide; and osteoporotic fractures are in the millions annually in the US alone and cost tens of billions of dollars. Characterization of bone quality in osteoporotic patients is important with respect to monitoring treatment efficacy, though currently quite limited. While some technical hurdles in developing a noninvasive diagnostic tool using low frequency vibration have been overcome, changes in the frequency response signal of bone have not been investigated at the various bone organizational levels. Our principal hypothesis is that the vibrational modes of bone tissue change significantly with the deterioration of bone micro-architecture and that these modes can be captured by noninvasive sensors.