Effect of Excipients on Lag Time of Press Coated Tablets in Pulsatile Drug Delivery For The Treatment of Rheumatoid Arthritis.

摘要

A tablet system consisting of cores coated with insoluble coating was prepared and evaluated as pulsatile drug delivery system for the treatment of rheumatoid arthritis. The dry-coated tablet with optimal lag time was designed to simulate the drug dosing time according to physiological needs. Press coated tablet was prepared with meloxicam, the drug of choice for the treatment of rheumatoid arthritis, in the core tablet & Ethyl cellose powder (EC) with fine particles , in the whole layer of the outer shell as insoluble coating . Along with this Spray Dried Lactose (SDL) and Hydroxy Propyl Methyl Cellulose ( HPMC) were mixed in different weight ratios with EC individually and its effect on the lag time of the drug release was investigated. The release profile exhibited a lag time followed by a rapid and complete release phase, in which the outer shell ruptured or broke into two halves and found that the lag time was dependent on the weight ratios of EC / SDL or EC/HPMC in the outer shell.