In vitro lung cell culture studies of particle-inducedproinflammatory responses

摘要

Recent work with soil-derived mineral dusts and manufactured nanoparticles will be discussedrnto illustrate the types of toxicological information that can be obtained from treatment of cellrncultures with low-solubility particles. Readily inhaled particulate matter (PM), which includesrnthe enriched PM2.5 fraction of certain soil dusts or modified manufactured nanoparticles, wasrnfound to cause release of the proinflammatory cytokine IL-6 to induce cell death in human lungrncell cultures. There is a need to include geological particulate matter when assessing adversernhealth effects of polluted air. Extensive prior cell culture research has been done byrntoxicologists to understand the effects and mechanisms of inhaled particles. Various surfacemodifyingrntreatments, including heat and leaching, were used to identify the particle componentsrnor characteristics that induced the cell signaling response.