Fabrication of Cu Nanowires and Its Effect on Proliferation of Mesenchymal Stem Cells

摘要

Many studies have focused on the fabrication of Cu nanowires due to their potential applications in diverse fields such as nanoelectronics and gene delivery. In this study, Cu nanowires were successfully fabricated with electrochemical deposition method. Cu nanowires was synthesized by electroplating from a 0.4M CuSO_4 bath, and the current was 0.005A. The length of nanowires can be controlled via changing deposition time. For cell research, serum coated and non-coated nanowires with the concentration of 10~2, 10~3, 10~4 and 10~5 were added to 96-well cell culture plate in which mesenchymal stem cells (MSCs) were pre-seeded. After incubating for 3 days, cytotoxicity of nanowires was measured. Results indicated that cytotoxicity increased as the increase of nanowires concentration. Serum coated nanowires had higher cell viability as compared with the non-coated group.