Functional Group Transformations at α-Carbon to Trifluoromethyl Group

摘要

This account summarizes the building methods of chiral α-carbon to trifluoromethyl group and further substitutions on that carbon. The preparations of the chiral trifluoromethylated compounds are relatively well studied. Meanwhile, the stereo-specific substitutions on the α-carbon to trifluoromethyl group should be developed to increase the versatility of synthetic strategies.