DEGRADATION OF POLY(ETHYLENE OXIDE)/POLY(ASPARTICACID) BIOMEDICAL SYSTEMS

摘要

Biomedical applications of polymers are becoming more common due to theirrnadvantageous properties which can be tailored in a preparation process [1-3].rnPolymeric drug carriers should meet several requirements for effective drug delivery,rnincluding water solubility, non-toxicity, non-immunogenicity, lack of long-termrnaccumulation in body, in vivo stability, selective delivery to the target site and arncapacity for the encapsulation of insoluble or poorly water-soluble drugs. Newrncontrolled drug delivery systems are also capable to respond to changes inrnenvironmental conditions, e.g. temperature, pH or UV light. Considering the form,rnmicro- and, recently, nanoparticles have played a considerable role as effective drugrndelivery devices. This particles could be easily manufactured in a reproducible mannerrnand represent an attractive alternative for improving the modulation of drug deliveryrnand stability in biological fluids. An important problem is stability towardrn(bio)degradation that should be well known. In our research we have performedrndegradation tests on poly(ethylene oxide)/poly(aspartic acid) systems which arerndesigned for biomedical applications.