The Protection Effect of Caffeic Acid Phenethyl Ester against Hepatic Damage by Cadmium Exposure

摘要

Aims: The aim of this study is to approach the possible effect and mechanism of caffeic acid phenethyl ester (CAPE) against the toxicity of Cd on mice liver. Methods: In vivo assays have been performed by evaluating the oxidative damage markers and the antioxidant parameters, meanwhile, the histopathological changes have also been observed. Results: It was revealed that the intoxication of Cd could increase the concentration of oxidative damage and decrease the content of antioxidant system, moreover, the impact of Cd on liver can be suppressed by the effect of CAPE (10μM/kg) by lowering the oxidative damage levels and improving the activities of SOD, GSH and CAT. Conclusion: From the data obtained from the studies, we found that the protection effect of CAPE on Cd toxicity was not solely dependent on the antioxidant effect, however, the evidence of CAPE playing a role in the amelioration of Cd toxicity probably supported that CAPE can be a promising agent in the treatment of Cd exposure.