Sentinel Lymph Node Biopsy in China: China multicenter study of sentinel node biopsy substituting axillary node dissection

摘要

1. China multicenter study of sentinel node biopsy substituting axillary node dissection: CBCSG-001 trial (2008 EBCC abs#403 update)Background China multicenter study of sentinel lymph node biopsy (SLNB) substituting axillary lymph node dissection (ALND) in breast cancer - CBCSG-001 trial was conducted from Jan. 2002 to Jun. 2007, with 1,970 SLNB pts recruitment. The primary objectives were 5ys DFS and complications between SLNB and ALND. The second objectives included 5ys OS, SLN intraoperative diagnosis, micrometastasis detection and prognosis, and radiologic safety. Materials and Methods Combined methylene blue dye and 99mTc-sulfur colloid or 99mTc-IT-Rituximab were used as tracers for SLNB. Preoperative lymphscintigraphy was mandatory for all pts. Pts with negative SLN did not receive ALND.