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The Inhibitory Effects of Chinese Herbal Effective Fractions on the Expression of EBV Early Antigen

机译:中药有效部位对EBV早期抗原表达的抑制作用

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With the application of the immune enzyme assay, the inhibitory effects of Chinese herbal effective fractions on the expression of Epstein-Barr virus (EBV) early antigen in Raji cell have been investigated. The test result shows that Astragalus polysaccharide (AP), Ganoderma lucidum polysaccharide (GLP) and Epimedium polysaccharide (EP) have inhibitory effects in certain range of dose. AP and GLP have significantly better inhibitory effects than EP. In addition, the inhibitory effects of these polysaccharides on EBV antigen expression have presented dose-effect relationships. In conclusion, this method can be used for finding new anti-EBV drugs in natural medicine. New anti-EBV drugs will inhibit EBV antigen expression and prevent cell carcinogenesis, so that they will be used for prevention and treatment of EBV associated disease. Furthermore the experiment reveals a new mechanism of herbal polysaccharides' anti-viral and anti-tumor effects.
机译:通过免疫酶联免疫吸附试验,研究了中草药有效部位对Raji细胞中爱泼斯坦-巴尔病毒(EBV)早期抗原表达的抑制作用。试验结果表明,黄芪多糖(AP),灵芝多糖(GLP)和淫羊poly多糖(EP)在一定剂量范围内均具有抑制作用。与EP相比,AP和GLP具有明显更好的抑制作用。另外,这些多糖对EBV抗原表达的抑制作用已经呈现出剂量-效应关系。总之,该方法可用于在天然药物中发现新的抗EBV药物。新的抗EBV药物将抑制EBV抗原表达并防止细胞癌变,因此将被用于预防和治疗EBV相关疾病。此外,该实验揭示了草药多糖具有抗病毒和抗肿瘤作用的新机制。

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