To evaluate the usefulness of MRIfor women with hereditary breast cancer risk in Taiwan.Ac-cording to the reports from our government，breast cancerhad become the second place of neoplasm in our female popu-lation.It also ranked the 5th place in cancer mortality.Thecontrol of breast cancer may be achieved by early detection，careful diagnosis and effective therapy.Prevention of breastcancer is still far remote in consideration.There are manyimaging modalities for breast examinations.They includedthe followings：conventional mammography(MG)，digitalmammography， ultrasonography (US)， computed tomo-graphy(CT)and magnetic resonance imaging(MRI).Methods：We retrospectively revealed the MRI examinationfor women with hereditary breast cancer risk form January2003 to June 2007.The MRI examinations were performedwith a 1.5 Tesla machine.The imaging sequence includes T1axisI and T2 axisl without Gadolinium contrast，T1 with fatsuppression and Gadolinium contrast,post-processing im-age subtraction was then performed.Time-signal intensitycurve performed when necessary.Most breast cancers en-hance rapidly and profoundly after the intravenous injectionof gadolinium--based contrast agents.The factors accountfor the enhancement are：secretion of tumor angiogenesis fac-tors(recruitment of new blood vessels)，increase in capillarypermeability，changes in osmolar pressure and expansion of the interstitial space.The contrast agents are distributed in the extracellular space after intravenous injection and tend toaccumulate in tissues with rich vascularity.The women withhereditary breast cancer risk had positive family history.Thepositive family history included a family member with breastcancer.The family member might be grandmother，mother,daughter and sister.Result：There were altogether 230 women received Mrlbreast examination.There were 28 women(8.2％)had post-tive family history.Twelve of them had positive finding inMRl examinations.All of them had histologiesl results.Nineof them found to have invasive breast cancer.The sensitivitywas 100％and the specificity was 68.4％.Conclusions：Offering MRI screening to high riskwomen is better than none at all.However there are ques-tions have to be answered for MRI used as screening tool forhigh risk patient.First，is MRI an effective test in the con-text of screening high risk women?Second，is there evidenceof benefit of screening high risk women with MRI?It is notyet clear whether the enhanced sensitivity of MRI will trans-Iate into a reduction in breast cancer related mortality.
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