Base Pairing within the psi_(32),psi_(39)-Modified Anticodon Arm of Escherichia coli tRNA~(phe)

摘要

The anticodon arm of tRNA is central to the accuracy and efficiency of protein synthesis.In addition to the three anticodon nucleotides,the extended anticodon hypothesis predicts that the sequence and modification state of nucleotides in the loop-proximal region of the anticodon arm can modulate the decoding function of tRNA.Consistent with this hypothesis is the influence that nucleotides 32 and 38 can have on the accuracy of translation and on the affinity of tRNA for the ribosome.