Total synthesis of cytotoxic macrolide amphidinolide B-1 and the proposed structure of amphidinolide B-2

摘要

The first enantioselective total syntheses of cytotoxic macrolide amphidinolide B, and the proposed structure for amphidinolide B-2 have been accomplished. Key features of the syntheses include a diastereoselective aldol condensation, a spontaneous Wadsworth-Emmons `macrocyclization and a directed epoxidation/elimination sequence.