Rhenium-Catalyzed Addition of Carbonyl Compounds to the Carbon-Nitrogen Triple Bonds of Nitriles: alpha-C-H Activation of Carbonyl Compounds

摘要

The ReH7(PPh3)(2)-catalyzed addition of carbonyl compounds to the carbon-nitrogen bond of nitrites proceeds efficiently and selectively to give the corresponding (Z)-enamines, which are important synthetic intermediates. The key step of the reaction is the chemoselective alpha-C-H activation of carbonyl compounds induced by the alpha-heteroatom effect in the presence of nitriles.