AbstractSeveral nucleic acid analogues as shown in Scheme 1 were synthesized by alternating copolymerization of nucleoside analogues with maleic anhydride or acrylic anhydride. These polymers showed similar physicochemical properties to those of the natural polymers, such as base‐pairing and base‐stacking. Polymer 3U, for example, formed 1:1 complex with poly(adenylic acid) by base‐pairing. Polymer4Ashowed 33 of hypochromicity compared with the UV‐absorption of adenosine due to the base‐stacking. Polymer5catalyzed the cleavage of DNA and the hydrolysis of phosphodiester with a rate acceleration of 103compared with the uncatalyzed
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