Synthesis and properties of tocopherol‐containing polymeric vesicle systems

摘要

AbstractTwo different tocopherol‐containing amphiphilic monomers, (tocopheryloxy)‐carbonyl ‐methyl 2‐(methacryloyloxy)ethyl dimethyl‐ammonium chloride(3a) and (tocopheryloxy)penta(ethoxy)carbonyl methyl 2‐(methacryloyloxy)ethyldimethylammonium chloride(3b), were synthesized and polymerized. The formation of polymeric closed vesicles having diameters ranging from 200 to 5200 Å was confirmed by electron micrographs, entrapment of 14Csucrose, permeability measurements and gel filtration. The polymeric vesicles showed reduced permeability and enhanced thermodynamic stability. Antioxidative activities were determined by the thiocyanate method confirming that polymeric tocopherols also exhibited significan