Preparation and anticoagulant surface properties of glucoside‐ or sulfated glucoside‐bearing polymer grafted poly(ethylene) films

摘要

AbstractPoly(GEMA) or poly(GEMA)‐sulfate grafted surfaces were prepared for the purpose of developing biomaterials with anticoagulant surfaces. Their functionalities were investigated as anticoagulant activity, proteins and cells adhesion activity, and complement activation activity. These results revealed that the adhesion of blood cells onto a GEMA‐sulfate grafted surface was due to protein adsorption and that complement activation onto a GEMA‐sulfate grafted surface was larger than that on a GEMA grafted surface. A GEMA‐sulfate grafted surface, however, exhibited good anticoagulant activity. These functions seemed to be due to the specific functionality of the SO3groups in a GEMA