Catalytic Asymmetric Synthesis of α-Amino Phosphonates Using Enantioselective Carbon-Carbon Bond-Forming Reactions

摘要

We have developed a highly enantioselelctive reaction of silicon enolates with N-acyl-α-iminophosphonates leading to nonracemic α-amino phosphonates. A copper (Ⅱ) complex was shown to be effective catalysts for this reaction, giving high yields and selectivities. It is noteworthy that this reaction opens a new pathway to various biologically important, nonracemic α-amino phosphonate derivatives. Studies into substrate variation, allowing access to libraries of α-amino phosphonates, and the application of this catalytic procedure to other reactions of N-acyl-α-iminophosphonates are currently underway in our laboratory.