Genome Mining To Identify New Plant Triterpenoids

摘要

Plants are sessile organisms that cannot flee or fight to avoid being consumed. As part of their defense mechanisms, plants biosynthesize tens of thousands of known natural products, many of which have medicinally useful properties. The triterpenoids are a major group of plant natural products that includes sterols, triterpene saponins, and related structures. We describe herein experiments in which exploiting Arabidopsis thaliana genomic information uncovered two new triterpenoids. Genome mining can uncover compounds that have eluded classical methodologies.