Translation of DNA into Synthetic N-Acyloxazolidines

摘要

DNA-templated organic synthesis (DTS) can (i) mediate diverse synthetic reactions to generate structures unrelated to the DNA backbone; (ii) direct the multistep synthesis of small molecules and polymers; (iii) enable new modes of controlling synthetic reactivity that cannot be realized using traditional synthesis methods;1d and (iv) allow the translation, in vitro selection,1h and amplification of libraries of DNA oligonucleotides encoding synthetic small molecules. Despite these advances, the synthetic capabilities of DTS are still in their infancy as compared with conventional organic synthesis. Indeed, only two DNA-templated multistep small-molecule syntheses have been described to date, comprising a tripeptide and a branched thioether. The development of increasingly sophisticated multistep DNA-templated syntheses is critical to maximize the functional potential of molecules discovered through DTS and selection-based1h methods.