Lipopolysaccharide Identification with Functionalized Polydiacetylene Liposome Sensors

摘要

Lipopolysaccharides (LPS) are complex glycolipids embedded within the outer membrane of Gram negative bacteria. Each cell contains over 2 million copies of LPS.1b LPS consists of a conserved lipidated disaccharide, known as Lipid A, which is attached to a core oligosaccharide fragment. The core region is extended by additional glycosylation to provide the O-specific antigen or polysaccharide region. The identity of these terminal sugars vary for different bacterial species and serotypes. Sensors which are capable of detecting and identifying different types of LPS can be used to develop devices for bacterial diagnostics.