Antibody Nanoarrays with a Pitch of approx 20 Nanometers

摘要

This communication reports a DNA-directed antibody self-assembly into two-dimensional (2D) arrays.The resulting antibody arrays present a well-defined tetragonal order with a repeating distance of approx 19 nm.DNA has robust physicochemical properties and predictable Watson-Crick base-pairing ability and provides a versatile molecular system for preparing nanometer-scale structures.Recent works have demonstrated that DNA motifs can self-assemble into millimeter-sized,well-ordered 2D arrays with features of nanometer scale,which greatly scales up the DNA-based self-assembly.