Palladium-Catalyzed Coupling of Ammonia and Lithium Amide with Aryl Halides

摘要

Ammonia is among the largest volume and least expensive bulk chemicals.Although ammonia is a common nitrogen source in chemical synthesis,it is rarely used as a reagent in catalytic processes.Because primary arylamines are important intermediates in the manufacture of agrochemicals,pharmaceuticals,dyes,pigments,and rubber,the palladium-catalyzed amination to form primary aromatic amines from aryl halides would be a synthetically valuable catalytic transformation of ammonia.However,no such reaction of ammonia has been reported.Instead,the palladium-catalyzed synthesis of primary arylamines has typically been accomplished with ammonia surrogates.