Synthesis of Homoallylic Amines via the Palladium-Catalyzed Decarboxylative Coupling of Amino Acid Derivatives

摘要

Due in part to their application in the synthesis of a variety of heterocycles that are commonly found in biologically active compounds,the synthesis of homoallylic amines has received much attention.Traditional approaches for the synthesis of homoallylic amines have focused on the addition of nucleophilic metal allyls to electrophilic aldimines.Herein we report a complementary route for the synthesis of protected homoallylic amines,which instead couples an electrophilic allyl moiety with an alpha-amino anion derived from an amino acid precursor.