Ehantioselective Synthesis of Axially Chiral Anilides through Rhodium-Catalyzed [2+2+2] Cycloaddition of 1,6-Diynes with Trimethylsilylynamides

摘要

Axially chiral anilides are valuable structures for asymmetric reactins and biologically active compounds,and various asymmetric syntheses of them have been reported.There are mainly based on a chiral pool method or an optical resolutin of racemic compounds,although the straightforward enantioselective synthesid is highly desired.