Elemental Tomography of Cancer-Cell Spheroids Reveals Incomplete Uptake of Both Platinum(Ⅱ) and Platinum(Ⅳ) Complexes

摘要

The limited penetration of cytotoxic drugs into tumors, a major component of multicellular resistance, is a significant contributing factor to the limited effectiveness of cancer chemotherapy. Clinically important drugs such as doxorubicin diffuse only 40— 100 μm from blood vessels and reach a fraction of the viable cells that make up a solid tumor. The multicellular tumor spheroid model is an in vitro system that has been extensively used to study the extent of anticancer drug penetration.