Enantioselective Metallophosphite-Catalyzed C-Acylation of Nitrones

摘要

This communication details the asymmetric metallophosphite-catalyzed 1,3-silylacylation of nitrones (eq 1). This reaction provides access to enantiomerically enriched N-aryl α-amino ketones and, to the best of our knowledge, constitutes the first example of direct C-acylation of nitrones.