Deuterium Exchange as an Indicator of Hydrogen Bond Donors and Acceptors

摘要

Hydrogen bonding is a fundamental feature in the structured folding of proteins and synthetic foldamers. As interest grows in peptidomimetic design and peptide catalysts, a heightened understanding of the hydrogen bonding properties of these molecules is essential. Herein we demonstrate that hydrogen/deuterium exchange is a valuable tool in determining the relative strengths of hydrogen bonds in relation to controls. Additionally, it provides a means to elucidate the separate roles of both hydrogen bond donors and hydrogen bond acceptors.