Low-Temperature Heck Reactions of Axially Chiral o-lodoacrylanilides Occur with Chirality Transfer:Implications for Catalytic Asymmetric Heck Reactions

摘要

Asymmetric Heck reactions promoted by chiral palladium catalysts were among the first catalytic asymmetric carbon-carbon bond forming reactions to be explored,and they have frequently been harnessed in natural product synthesis.Cyclizations of o-iodoanilides,pioneered by Overman and co-workers,have proven value in alkaloid synthesis.