Spirastrellolide B Reveals the Absolute Configuration of the Spirastrellolide Macrolide Core

摘要

Spirastrellolide A (1) represents the first example of a new family of biologically active macrolides obtained from extracts of the marine sponge Spirastrella coccinea collected in Dominica.It was initially isolated by our group because it showed strong activity and an unusual phenotypic response in a cell-based assay used to discover new natural product antimitotic agents.