A General and Highly Selective Chelate-Controlled Intermolecular Oxidative Heck Reaction

摘要

C-C bond forming reactions are vital to the synthesis of natural products and Pharmaceuticals. The intermolecular Heck reaction is unique among cross-coupling reactions due to the direct formation of C-C bonds from vinylic C-H bonds of α-olefins. The inertness of α-olefins relative to the oxidized substrates needed for other C-C bond forming methods means that fewer steps are required for their installation and maintenance throughout a synthetic sequence. Despite significant advances in the scope of the arylating reagent, the intermolecular Heck reaction has enjoyed limited application in complex molecule synthesis due to restricted olefin scope.